Understanding Biology of Mental Disorders

Understanding mental disorders through Woody Allen's films.

Understanding illness experiences of employees with common mental health disorders.

BACKGROUND Common mental health disorders (CMHDs) are a leading cause of sickness absence. To address this, a Fit for Work Service (FFWS) was introduced in Greater Manchester, UK, in 2010, offering case-managed and multidisciplinary interventions to early-stage sickness absentees experiencing physical health conditions and/or associated psychosocial problems, to enable a speedy return to work. ...

Metabolic phenotyping and systems biology approaches to understanding neurological disorders

The development of high-throughput metabolic profiling and the study of the metabolome are particularly important in brain research where small molecules or metabolites play fundamental signalling roles: neurotransmitters, signalling lipids, osmolytes and even ions. Metabolic profiling has shown that metabolic perturbations in the brain go beyond alterations of neurotransmission and that variat...

An Evolutionary Biology Approach to Understanding Neurological Disorders

Many common human neurological disorders, including epilepsy, Alzheimer’s disease, Parkinson’s disease, autism spectrum disorders, and schizophrenia show complex heritability and genetics. While studies of single-gene diseases typically provide a more straightforward opportunity to understand the underlying molecular mechanisms of disease, complex diseases are more common and inherently more di...

SYSTEMS BIOLOGY: The Solution to Understanding Alcohol-Induced Disorders?